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Cancer can be one of the most devastating diagnoses in the world. The impact of cancer is far-reaching for both the patient and their loved ones. Even though we spent decades in cancer research, there is still no definitive cure for it. The grueling nature of this disease is always making scientists look for alternative theories. One such promising topic is Apigenin and Cancer Chemoprevention.
Apigenin’s anti-cancer properties can help prevent cancer. Modern research increasingly focuses on Apigenin’s ability to complement other cancer treatments. In this article, we will explore how Apigenin may help to prevent and combat various types of cancer.
Apigenin belongs to the flavone class of flavonoids. It is found in many fruits, including pineapples, grapefruit, oranges, and apples. Also, vegetables and herbs include onions, parsley, chamomile tea, celery, and wheat sprouts. Apigenin has been used in traditional medicine for its antioxidant, antimicrobial, antihypertensive, and anti-diabetic effects. You can also find Apigenin in organic red wine and beer.
For centuries, Apigenin was used in medicine for its calming effects. However, modern research has expanded our understanding of apigenin’s health benefits. According to studies, Apigenin has some antioxidant, anti-inflammatory, and neuroprotective properties. These properties of Apigenin may help with the prevention and treatment of cancer. For example, it can help inhibit the growth of cancer cells and induce apoptosis.
To understand Apigenin’s potential role in cancer, we should first discuss how cancer works. Genetic mutations and environmental factors can cause cancer. Cancer can lead to disruption of normal cellular processes and uncontrolled cell growth, which can in some cases invade other parts of the body.
Conventional cancer treatments come with significant side effects and a low success rate. As a result, there is an increased interest in natural compounds like Apigenin. Researchers have been studying Apigenin and cancer chemoprevention for years. Some laboratory and animal studies show Apigenin as an alternative approach. Let’s look at some of the mechanisms of Apigenin for anti-cancer treatment.
The cell cycle, a complex process by which cells grow and divide, is a key area of study in cancer research. Apigenin, a natural compound, has been found to have significant effects on this process. It can induce cell cycle arrest at the G2/M phase, increase p21 levels, and inhibit CDK1 and CDK2 in prostate cancer cells, all of which are crucial for regulating the progression of the cell cycle.
Furthermore, Apigenin can activate p53, a tumor suppressor protein whose activation can promote programmed cell death. All of these mean that Apigenin can stop the cells from dividing. Therefore, the cancer cells can not multiply, and the disease’s progression slows.
Programmed cell death, or apoptosis, is a crucial process in the body. Apoptosis is a natural process of the body. Through apoptosis, our body can remove damaged or unwanted cells. Cancer cells are notorious for evading apoptosis. Therefore, they can increase or divide uncontrollably. However, Apigenin can induce apoptosis even in cancer cells. It activates the intrinsic pathway. The pathway releases cytochrome C from mitochondria. Cytochrome C activates caspase enzymes. These can help to execute apoptosis in cells.
Apigenin can also increase pro-apoptotic protein expression and decrease anti-apoptotic protein expression, further promoting cancer cell death. For example, Apoptotic Protein can modulate key apoptotic protein expression in breast cancer cells. So, any cancer cells resistant to conventional treatment may respond positively to Apoptotic Protein.
A tumor requires a regular supply of nutrients and oxygen. The stimulation of new blood vessels can provide these essential elements to tumors, which is why the formation of new blood vessels is necessary for tumor growth. This process is known as angiogenesis.
Apigenin can inhibit a key protein of angiogenesis, vascular endothelial growth factor (VEGF). Inhibition of VEGF can inhibit the formation of new blood vessels, so Apigenin can cut off the resource supply to tumors. For example, a mouse model of melanoma was treated with Apigenin. It significantly reduced the number of new blood vessels and decreased tumor growth.
Apigenin is a powerful antioxidant. Therefore, it can enhance the activities of antioxidant enzymes. Some common enzymes include catalase, peroxidase, superoxide dismutase (SOD), and glutathione. The antioxidant capacity can protect cells from DNA damage of a malignant nature.
Chronic inflammation can influence the development of cancer. Here, Apigenin and cancer chemoprevention go hand in hand. Because the Cyclooxygenase-2 (COX-2) enzyme is overexpressed in some inflammatory cancers, Apigenin can decrease Cox-2 expression and reduce cancer progression. Apigenin can also modulate the production of some inflammatory cytokines. For example, it can lower levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). These are all involved in inflammation and cancer.
Sometimes, cancer cells can spread to distant parts of the human body. This process is known as metastasis. It is a major cause of mortality in cancer. Apigenin can potentially prevent metastasis. Let’s look at how Apigenin can do that below:
Matrix metalloproteinase (MMP) activity can break down the outer layer of the matrix. The breakdown helps cancer cells invade surrounding tissues. Apigenin can inhibit the MMP’s activity. Therefore, it can reduce cancer cell progression and prevent metastasis. In human breast cancer cells, Apigenin treatment reduced MMP-9 expression. Therefore, there was a decreased level of metastasis from the breast to surrounding tissues,
Chemotherapy and radiation are the most common forms of cancer therapies. However, they can also cause severe reactions in the recipient’s body, making them very difficult for most patients. Apigenin can help sensitize cancer cells to chemotherapy drugs. It can also protect normal cells from radiation and reduce the horrible side effects. According to one study, Apigenin can enhance the cytotoxic effects of cisplatin, a chemotherapy drug for ovarian cancer cells. The combined impact of Apigenin and cisplatin can increase cell death and reduce toxicity.
Apigenin shows great promise in the field of cancer research. We can incorporate a variety of Apigenin dietary sources into our routine. It can be a natural way to prepare our body for the fight against cancer. However, we should remember that advanced research is still ongoing. We still do not have the full picture of Apigenin and cancer chemoprevention. We may discover even more benefits of Apigenin along the way. For now, consult with your healthcare provider before any significant dietary changes, especially if you are undergoing cancer treatment.
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